Pediatric Hematology, Oncology and Hematopoietic Cell&Gene Therapy Area
Molecular Diagnostic of Non Hodgkin Lymphoma
Prof. Lara Mussolin
Principal Investigator
Research Activity
Our research area is dedicated mainly to the study and characterization of Non-Hodgkin lymphoma of childhood. The general approach includes the analysis of molecular mechanisms of tumorigenesis with a translational approach aimed to transfer biological results from the bench to clinical trials. This lab makes part of an international consortium with the aim to identify novel therapies and biomarkers with a particular focus regarding the role of liquid biopsy in these hematological malignancies.
Team Members
Prof. Lara Mussolin – Principal Investigator
Dr. Gaia Martire – PhD Student
Dr. Lavinia Ferrone – Post Doc
Dr. Carlotta Caterina Damanti – Post Doc
Dr. Matteo Marzi – PhD Student
Dr. Rebekka Salzmann – PhD Student
Dr. Alessia Danieli – PhD Student
Dr. Domenico Rizzato – Research Fellow
Dr. Elisa Tosato – Senior Technologist/Research Associates
Selected Publications
• Martire G, Lovisa F, Carraro E, Rizzato D, Cesaro S, Mura RM, Tondo A, Bertolin C, Boaretto F, Salviati L, Biffi A, Pillon M, Mussolin L. TP53 DNA binding domain mutational status and rituximab-based treatment are independent prognostic factors for pediatric Burkitt lymphoma patients stratification. Haematologica. 2024 Feb 22. doi: 10.3324/haematol.2023.284868. Epub ahead of print. PMID: 38385281.
• Damanti CC, Ferrone L, Gaffo E, Garbin A, Tosato A, Contarini G, Gallingani I, Angioni R, Molon B, Borile G, Carraro E, Pillon M, Scarmozzino F, Dei Tos AP, Pizzi M, Ciscato F, Rasola A, Biffi A, Bortoluzzi S, Lovisa F, Mussolin L. Plasma small-extracellular vesicles enriched in miR-122-5p promote disease aggressiveness in pediatric anaplastic large-cell lymphoma. Cancer Commun (Lond). 2023 May;43(5):630-634. doi: 10.1002/cac2.12415. Epub 2023 Apr 4. PMID: 37014813; PMCID: PMC10174085.
• Damm-Welk C, Lovisa F, Contarini G, Lüdersen J, Carraro E, Knörr F, Förster J, Zimmermann M, Sala A, Vinti L, Tondo A, Pillon M, Woessmann W, Mussolin L. Quantification of Minimal Disease by Digital PCR in ALK-Positive Anaplastic Large Cell Lymphoma: A Step towards Risk Stratification in International Trials? Cancers (Basel). 2022 Mar 27;14(7):1703. doi: 10.3390/cancers14071703. PMID: 35406475; PMCID: PMC8996924.
• Garbin A, Lovisa F, Holmes AB, Damanti CC, Gallingani I, Carraro E, Accordi B, Veltri G, Pizzi M, d’Amore ESG, Pillon M, Biffi A, Basso K, Mussolin L. miR-939 acts as tumor suppressor by modulating JUNB transcriptional activity in pediatric anaplastic large cell lymphoma. Haematologica. 2021 Feb 1;106(2):610-613. doi: 10.3324/haematol.2019.241307. PMID: 32299901; PMCID: PMC7849582.
• Lovisa F, Binatti A, Coppe A, Primerano S, Carraro E, Pillon M, Pizzi M, Guzzardo V, Buffardi S, Porta F, Farruggia P, De Santis R, Bulian P, Basso G, Lazzari E, d’Amore ESG, Bortoluzzi S, Mussolin L. A high definition picture of key genes and pathways mutated in pediatric follicular lymphoma. Haematologica. 2019 Sep;104(9):e406-e409. doi: 10.3324/haematol.2018.211631. Epub 2019 Feb 28. PMID: 30819919; PMCID: PMC6717562.