Regenerative Medicine Area

The Regenerative Medicine area includes four distinct yet deeply intertwined lines of research. By joining the expertise in tissue engineering, physiology and pathophysiology, the area aims at:

• studying the application of extracellular vesicles as therapeutic tools in inflammatory and autoimmune diseases involving organs such as the lung and the intestine;
• creating in vitro 3D model to study the cross-talk between cells and extracellular matrix in muscle such as rhabdomyosarcoma, the most common and aggressive soft tissue sarcoma in childhood;
• developing a biological ink, starting from the decellularized diaphragm extracellular matrix, mixed with the cells that constitute the tissue under physiological conditions, to apply a personalized regenerative medicine treatment for congenital diaphragmatic hernia by 3D bioprinting approach;
• generating 3D models of human skeletal muscle equipped with neuronal network, by combining human induced pluripotent stem cell technology and biomaterial science, for the identification of cellular and molecular players involved in neuromuscular disorders, including muscular dystrophies.