Medical Biotecnology Area

Biomedical Applications of Multiscale Engineering Technologies (BIAMET)

Prof. Elisa Cimetta

Principal Investigator

Research Activity

The laboratory’s main research interests focus on the application of engineering principles to biological studies. In particular, the BIAMET laboratory (Biomedical Applications of Multiscale Engineering Technologies) specializes in the design and development of advanced microscale technologies, microbioreactor platforms, and organ-on-chip devices for the in vitro culture of cells. The goal of the research is the optimization of biological models for their application in clinical settings for a better understanding of the mechanisms of the diseases and develop and test novel drugs and therapeutic strategies.

Team Members

Prof. Elisa Cimetta – Principal Investigator
Dr. Sara Micheli – Research Fellow
Dr. Pina Fusco – Research Fellow
Dr. Veronica Zingales – Research Fellow
Dr. Anna Fietta – PhD Student
Dr. Eleonora Zanre – PhD Student
Dr. Federico Maggiotto – PhD Student
Dr. Eva Dalla Valle – PhD Student

Selected Publications

• Fusco P, Fietta A, Esposito MR, Zanella L, Micheli S, Bastianello A, Bova L, Borile G, Germano G, Cimetta E. miR-210-3p enriched extracellular vesicles from hypoxic neuroblastoma cells stimulate migration and invasion of target cells. Cell & Bioscience, 2023 May;13:1,89. 10.1186/s13578-023-01045-z
• Micheli S, Mocellin P, Sorgato M, Bova L, Cimetta E. Modeling-based design specifications for microfluidic gradients generators for biomedical applications. Biochemical Engineering Journal 181 (2022) 108415. 10.1016/j.bej.2022.108415
• Bova L, Maggiotto F, Micheli S, Giomo M, Sgarbossa P, Gagliano O, Falcone D, Cimetta E. A porous gelatin methacrylate-based material for 3D cell-laden constructs. Macromolecular Bioscience, 2023 Feb;23(2):e2200357. 10.1002/mabi.202200357
• Zingales V, Esposito MR, Quagliata M, Cimetta E, Ruiz MJ. “Comparative Study of Spheroids (3D) and Monolayer Cultures (2D) for the In Vitro Assessment of Cytotoxicity Induced by the Mycotoxins Sterigmatocystin, Ochratoxin A and Patulin”. Foods 2024, 13(4), 564; https://doi.org/10.3390/foods13040564
• Micheli S, Piunti C, Sorgato M, Lucchetta G, Cimetta E. “Cancer-on-a-Chip Platform to Study Metastatic Microenvironments”. Chemical Engineering Transactions 2022, 93, 10.3303/CET2293036